Experts make new progress in Norovirus replication and antiviral research
December 20, 2017 Source: Xinhuanet
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Infectious diarrhea caused by Norovirus is prevalent throughout the world, and the infected population covers the entire age group, affecting about 684 million people each year. The latest research by the Wuhan Institute of Virology of the Chinese Academy of Sciences and the University of Cambridge, Imperial College, Wuhan University and other experts reveals the role and mechanism of Norovirus ribonucleic acid replication, providing new ideas for the development of the world's anti-Norovirus drugs. .
According to Zhou Xi, a researcher at the Wuhan Institute of Virology, Chinese Academy of Sciences, Norovirus is a positive-stranded ribonucleic acid virus. There are no vaccines and antiviral drugs against Norovirus.
He said that in the process of ribonucleic acid replication, the viral-encoded helicase and ribonucleic acid chaperones are thought to play an important role in unraveling the ribonucleic acid duplex produced by the replication process and reshaping the viral ribonucleotide conformation. effect. However, for Noroviruses and even caliciviruses, whether their coding for helicase or ribonucleic acid chaperones has been unknown has also hampered our understanding of the replication mechanisms of such important human viruses.
In the study, experts found that the unwinding function of Norovirus-non-structural protein can promote the replication of Norovirus ribonucleic acid, which is crucial for the replication and virus activity of Norovirus. Related studies have found that Norovirus and calicivirus encode viral proteins with ribonuclease and chaperone activity.
This research has deepened our understanding of the replication mechanism of this important pathogen virus, and the related research results have recently been published online in the international journal of virology, Journal of Virology.
Measuring Bowl, Medical Bowl, Plastic Measuring Bowl, Medical Measuring Bowl, Medical Plastic Measuring Bowl,
Measuring Bowl, Medical Bowl, Plastic Measuring Bowl, Medical Measuring Bowl, Medical Plastic Measuring Bowl
Luck Medical Consumables Co.,LIMITED , https://www.luckmedical.com